MyLungCancerTeam

What does it mean to have ROS1-positive lung cancer?

ROS1-positive means your lung cancer has a mutation in the ROS1 gene. This occurs in about 1 to 2 percent of people with non-small cell lung cancer (NSCLC). It's usually seen in people who don't have other common mutations like EGFR, ALK, or KRAS.

The good news is that Show Full Answer

What does it mean to have ROS1-positive lung cancer?

ROS1-positive means your lung cancer has a mutation in the ROS1 gene. This occurs in about 1 to 2 percent of people with non-small cell lung cancer (NSCLC). It's usually seen in people who don't have other common mutations like EGFR, ALK, or KRAS.

The good news is that identifying ROS1-positive status helps guide treatment decisions. There are several targeted therapy drugs specifically designed to block the abnormal ROS1 proteins that cause cancer cells to grow.

FDA-approved ROS1 inhibitors include:
- Ceritinib (Zykadia)
- Crizotinib (Xalkori)
- Entrectinib (Rozlytrek)
- Lorlatinib (Lorbrena)
- Repotrectinib (Augtyro)
- Taletrectinib (Ibtrozi)

These targeted therapies work by blocking the function of the mutated ROS1 protein, which can slow or stop tumor growth. Your eligibility for these treatments requires confirmation of ROS1 rearrangement through molecular testing of your cancer cells.

Talk with your oncologist about which ROS1 inhibitor might be the best option for your specific situation, as treatment choice depends on factors like whether you've had prior treatment and your overall health status.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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