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Real members of MyLungCancerTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyLungCancerTeam Member asked a question 💭
Melstone, MT

Since I started maintenance therapy with Pembrolizumab (Keytruda), my inner ears have felt blocked, which they are not, and the inside of my ears is very itchy.

June 14
 · 
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MyLungCancerTeam

That sounds really uncomfortable, and it's completely understandable to want to know if others have experienced this too. Itching is a known side effect of Pembrolizumab (Keytruda), and while it's most commonly reported on the skin of the arms, chest, and face, itching can show up in unexpected places — including the ears.

Show Full Answer

That sounds really uncomfortable, and it's completely understandable to want to know if others have experienced this too. Itching is a known side effect of Pembrolizumab (Keytruda), and while it's most commonly reported on the skin of the arms, chest, and face, itching can show up in unexpected places — including the ears.

Some MyLungCancerTeam members have reported itching as a side effect of immunotherapy, with some describing it as quite bothersome. The blocked feeling you're describing, even when your ears aren't actually blocked, could be related to how your immune system is responding to the treatment. Here are some important things to keep in mind:

- Don't ignore it — let your oncology team know about this symptom, especially since Keytruda can sometimes cause the immune system to overreact and affect different parts of the body
- Avoid putting anything in your ears without medical advice, as this could make things worse
- Ask about safe relief options — your doctor may recommend topical or oral treatments to help manage the itching

It's always best to flag new or changing symptoms to your care team, even if they seem minor. They can help determine whether it's a manageable side effect or something that needs closer attention.

June 14

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