I have been put on Pemetrexed as my only treatment. I have my third one next week. Unfortunately I do not have any of the markers that allows me the new less toxic drugs. My oncologist said I can do it as long as my body tolerate the side effects but she also said that it will damage my health. I feel horrible on it. I feel tired from morning to night, headaches, pain in my mouth and many other concerns. I did it earlier w the carboplatin and keytruda and it did not affect me as much…Hope this helps.

The stuff works. Be grateful as it's overall only 40 minutes every 3 weeks.

I've been on nothing but Keytruda, every 3 weeks, for about a year and
nothing. Eonder what the Dr. will try next? I'm getting tired of this
recliner.

Thank you Julie! That's what they are telling me, but I have trust issues. Lol

In my experience the side effects of pemetrexed alone are mild relative to carboplatin+pemetrexed. With C+P I would experience significant fatigue on days 4 and 5, slowly getting back to normal energy levels after a couple of weeks. I also had mouth sores. With pemetrexed alone the fatigue has been less and the bounce-back has been faster, and no more mouth sores. I've had 4 rounds of pemetrexed alone so far.